Synergistic Action of Hesperidin and Quercetin Modulate the Efficacy of CCl4 -Induced Nephrotoxicity in Rat Model
Grace Ekpo, Sampson Ekam Victor, Ofem Effiom Eteng, Richard Ebena, Ndodo Ofonime, Ezekiel. U. Umoh, Onofiok Luke Uduak, Saviour Ufot, Ubana Eyong Eyong
Abstract
Chemical toxicants are hazardous compounds that can cause oxidative processes that lead to detrimental metabolites for human health when inhaled, consumed, or come into touch with the surface of the skin. Quercetin and hesperidin's effects on carbon tetrachloride (CCl4)-induced nephrotoxicity were examined using a rat model. After being exposed to CCL4 (0.5 mg/kg), rats were gavaged with quercetin and hesperidin (2.4, 2.4, and 1.4 mg/kg each) for twenty-one days. To assess several biochemica
Topics & Concepts
HesperidinQuercetinNephrotoxicityPharmacologyChemistryAction (physics)MedicineBiochemistryAntioxidantToxicityPathologyAlternative medicinePhysicsQuantum mechanicsOrganic chemistryDrug-Induced Hepatotoxicity and ProtectionPhytochemicals and Antioxidant ActivitiesPharmacological Effects of Natural Compounds