The mitochondria-targeted small molecule SS31 delays progression of behavioral deficits by attenuating β-amyloid plaque formation and mitochondrial/synaptic deterioration in APP/PS1 mice
Yanli Jia, Wei Wang, Ning Han, Sun Hong-liang, Fangming Dong, Ya‐Xue Song, Rong-Fang Feng, Jianhua Wang, Jianhua Wang
Topics & Concepts
SynaptophysinMitochondrionHippocampusMitochondrial fissionGenetically modified mouseBiologyTransgeneAmyloid precursor proteinPostsynaptic densitySynapsin IPostsynaptic potentialCognitive declineSynaptic plasticityNeuroscienceAlzheimer's diseaseCell biologySynaptic vesicleInternal medicineMedicineDementiaDiseaseImmunohistochemistryBiochemistryImmunologyReceptorVesicleGeneMembraneAlzheimer's disease research and treatmentsTryptophan and brain disordersBiochemical effects in animals