Decarboxylation in Natural Products Biosynthesis
Nguyet A. Nguyen, Jacob H. Forstater, John A. McIntosh
Abstract
Decarboxylation reactions are frequently found in the biosynthesis of primary and secondary metabolites. Decarboxylase enzymes responsible for these transformations operate via diverse mechanisms and act on a large variety of substrates, making them appealing in terms of biotechnological applications. This Perspective focuses on the occurrence of decarboxylation reactions in natural product biosynthesis and provides a perspective on their applications in biocatalysis for fine chemicals and pharmaceuticals.
Topics & Concepts
DecarboxylationBiosynthesisNatural productBiocatalysisChemistryBiochemistryEnzymeBiochemical engineeringCatalysisReaction mechanismEngineeringBiochemical and biochemical processesPlant biochemistry and biosynthesisMicrobial Metabolic Engineering and Bioproduction