Multi-omics reveals microbiome, host gene expression, and immune landscape in gastric carcinogenesis
Chan Hyuk Park, Changjin Hong, A-reum Lee, Jaeyun Sung, Tae Hyun Hwang
Abstract
, which regulates mitosis and cell cycle time. Furthermore, lower abundances of B cell signatures in gastric cancer compared to gastritis may suggest a previously unidentified immune evasion process in gastric carcinogenesis. Our study provides the most comprehensive description of microbial, host transcriptomic, and immune cell factors of the gastric carcinogenesis pathway.
Topics & Concepts
CarcinogenesisBiologyTranscriptomeMicrobiomeGastritisImmune systemCancerGene expressionCancer researchHelicobacter pyloriGeneComputational biologyImmunologyBioinformaticsGeneticsHelicobacter pylori-related gastroenterology studiesGut microbiota and healthRNA modifications and cancer