A virulence factor as a therapeutic: the probiotic <i>Enterococcus faecium</i> SF68 arginine deiminase inhibits innate immune signaling pathways
Fereshteh Ghazisaeedi, Jochen Meens, Bianca Hansche, Sven Maurischat, Peter Schwerk, Ralph Goethe, Lothar H. Wieler, Marcus Fulde, Karsten Tedin
Abstract
SF68 is responsible for inhibition of host cell NF-κB and JNK(AP-1) pathway activation, and is likely to be responsible for the anti-inflammatory and immunomodulatory effects observed in prior clinical human and animal trials. The implications for the use of this probiotic strain for preventive and therapeutic purposes are discussed.
Topics & Concepts
Enterococcus faeciumBiologyArginine deiminaseMicrobiologyInnate immune systemImmune systemProbioticImmunologyArginineBacteriaBiochemistryAntibioticsGeneticsAmino acidAntimicrobial Peptides and ActivitiesProbiotics and Fermented FoodsCancer Research and Treatments