Energy expenditure due to gluconeogenesis in pathological conditions of insulin resistance
Emmanuel Quaye, Shaji Chacko, Stephanie T. Chung, Robert J. Brychta, Kong Y. Chen, Rebecca J. Brown
Abstract
Gluconeogenesis is an energy-requiring process that is upregulated in diabetes, contributing to hyperglycemia. Previous studies have estimated that gluconeogenesis accounts for less than 10% of resting energy expenditure. This study estimates the energy expenditure attributable to gluconeogenesis in uncommon and severe forms of insulin resistance and common, milder forms of insulin resistance. In these populations, gluconeogenesis accounts for almost one-third of resting energy expenditure, substantially higher than previously theorized in the literature.
Topics & Concepts
GluconeogenesisInsulin resistanceEnergy expenditureInsulinPathologicalResistance (ecology)Internal medicineEndocrinologyMedicineBiologyMetabolismEcologyDiet and metabolism studiesMetabolism, Diabetes, and CancerDiet, Metabolism, and Disease