Aichi virus 3C protease modulates LC3- and SQSTM1/p62-involved antiviral response
Ming-Hsiang Kung, You-Sheng Lin, Tsung-Hsien Chang
Abstract
This study reveals a possible mechanism of autophagy-associated proteins regulating virus replication. Maintaining a cellular level of LC3 and p62 during the viral infection period might help restrict virus replication. Although, AiV 3C protease dampens the LC3 and p62-mediated host antiviral machinery for AiV replication. Results obtained provide a better understanding of the molecular pathogenesis of AiV for developing methods of prevention and treatment.
Topics & Concepts
AutophagyBiologyVirusViral replicationVirologyCell biologyProteaseGene knockdownViral proteinGeneEnzymeBiochemistryApoptosisAutophagy in Disease and TherapyViral Infections and VectorsCytomegalovirus and herpesvirus research