Antisense Oligonucleotide Therapy Targeted Against ATXN3 Improves Potassium Channel–Mediated Purkinje Neuron Dysfunction in Spinocerebellar Ataxia Type 3
David D. Bushart, Annie J. Zalon, Hongjiu Zhang, Logan M Morrison, Yuanfang Guan, Henry L. Paulson, Vikram G. Shakkottai, Hayley S. McLoughlin
Topics & Concepts
Spinocerebellar ataxiaNeurosciencePurkinje cellMotor neuronCerebellumBiologyAtaxiaCerebellar ataxiaMachado–Joseph diseaseDeep cerebellar nucleiCerebellar cortexSpinal cordGenetic Neurodegenerative DiseasesMitochondrial Function and PathologyIon channel regulation and function