Cascade Nucleophilic Addition–Cyclic Michael Addition of Arynes and Indoles Bearing Michael Acceptor: A Strategy to Construct Pyrroloacridines and Study of Their Physicochemical Properties
Gurupada Hazra, Sayantan Kundu, Rambabu Dandela, Barla Thirupathi
Abstract
A facile synthetic approach to 6 H -pyrrolo[3,2,1- de ]acridines has been developed by using cascade N -nucleophilic addition–cyclic Michael addition process of arynes and indoles substituted with Michael acceptors under metal-free conditions. Additionally, photophysical studies of a few of the newly synthesized pyrroloacridine compounds indicated good fluorescence emission properties.
Topics & Concepts
Michael reactionAryneCascadeNucleophilic additionChemistryNucleophileAcceptorCombinatorial chemistryOrganic chemistryCatalysisPhysicsChromatographyCondensed matter physicsCyclization and Aryne ChemistryChemical synthesis and alkaloidsSynthesis and Biological Evaluation