Fluctuation in O-GlcNAcylation inactivates STIM1 to reduce store-operated calcium ion entry via down-regulation of Ser621 phosphorylation
Atsuo Nomura, Shunichi Yokoe, Kiichiro Tomoda, Takatoshi Nakagawa, Francisco Javier Martı́n-Romero, Michio Asahi
Abstract
-GlcNAcylation could provide a promising treatment option for the related diseases, such as neurodegenerative diseases.
Topics & Concepts
HEK 293 cellsSTIM1TransfectionPhosphorylationChemistryCell biologyImmunoprecipitationCalciumBiologyBiochemistryEndoplasmic reticulumReceptorGeneOrganic chemistryIon Channels and ReceptorsToxin Mechanisms and ImmunotoxinsSignaling Pathways in Disease