Amino Acid and Acylcarnitine Levels in Chronic Patients with Schizophrenia: A Preliminary Study
Irina A. Mednova, Alexander А. Chernonosov, Marat F. Kasakin, Elena G. Kornetova, A. Semke, Н. А. Бохан, Vladimir V. Koval, Svetlana А. Ivanova
Abstract
Amino acids and acylcarnitines play an important role as substrates and intermediate products in most of pathways involved in schizophrenia development such as mitochondrial dysfunction, inflammation, lipid oxidation, DNA damage, oxidative stress, and apoptosis. It seems relevant to use an integrated approach with 'omics' technology to study their contribution. The aim of our study was to investigate serum amino acid and acylcarnitine levels in antipsychotics-treated patients with chronic schizophrenia compared with healthy donors. We measured serum levels of 15 amino acids and 30 acylcarnitines in 37 patients with schizophrenia and 36 healthy donors by means of tandem mass spectrometry. In summary, patients with chronic schizophrenia had an altered concentration of a few amino acids and acylcarnitines in comparison to the healthy probands. Further research is needed to assess and understand the identified changes.