Evaluation of the effects of newly synthesized metallophthalocyanines on breast cancer cell lines with photodynamic therapy
Hayrani Eren Bostancı, Ahmet T. Bilgiçli, Emre Güzel, Armağan Günsel, Ceylan Hepokur, Behzat Çimen, M. Nilüfer Yaraşır
Abstract
, respectively. In the LDH (lactate dehydrogenase)-ELISA study, the LDH levels that formed on a cellular basis after the application were measured, and it was observed that the cells were directed towards apoptosis. In addition, it was observed that cancer cells underwent more apoptosis than healthy cells as a result of this application with cell-cycle and dead cell kits performed by flow cytometry. This research shows that non-peripheral substituted gallium and zinc phthalocyanine derivatives (2 and 6) can be suitable photosensitizers for the photodynamic treatment of breast cancers.
Topics & Concepts
Photodynamic therapyBreast cancerCancer researchCancer cell linesCancerCancer therapyOncologyMedicineInternal medicineChemistryCancer cellOrganic chemistryPorphyrin and Phthalocyanine ChemistryPhotodynamic Therapy Research StudiesNanoplatforms for cancer theranostics