Brønsted acidic ionic liquid-catalyzed tandem reaction: an efficient and sustainable approach towards the regioselective synthesis and molecular docking studies of 4-hydroxycoumarin-substituted indoles bearing lower <i>E</i>-factors
Satyajit Samanta, Rana Chatterjee, Subhankar Kumar Sarkar, Satyajit Pal, Anindita Mukherjee, Ilya I. Butorin, Olga A. Konovalova, Tathagata Choudhuri, Koushik Chakraborty, Sougata Santra, Grigory V. Zyryanov, Adinath Majee
Abstract
-factors. A clean reaction, easily accessible reactants, metal-free and environmentally friendly reaction conditions, and reusability of the catalyst are the notable advantages of this procedure. In addition, molecular docking studies show the theoretical possibility of binding these types of synthesized compounds to key proteins in tumorigenesis.
Topics & Concepts
ChemistryCatalysisIndole testCascade reactionCombinatorial chemistryAnilineImineIonic liquidNucleophilic additionRegioselectivityBrønsted–Lowry acid–base theoryOrganic chemistryMulticomponent Synthesis of HeterocyclesSynthesis of Indole DerivativesSulfur-Based Synthesis Techniques