Photocatalyzed Site-Selective Formal β-C(sp <sup>3</sup> )–H Sulfonylation of Ketones with Sulfinates
Jun Xu, Jingyi Zhang, Zhixiong Wang, Jian Li, Jiabin Shen, Pengfei Zhang
Abstract
)-H sulfonylation of ketones. This method operates under mild conditions and exhibits broad functional group compatibility. Its utility is demonstrated through scalable synthesis and the late-stage functionalization of complex molecules. Mechanistic investigations suggest a reaction pathway involving a photoinduced hydrogen atom transfer (HAT) step, followed by copper-mediated reductive elimination. This protocol provides a direct route to valuable β-sulfonyl ketones from readily available starting materials and inexpensive reagents.
Topics & Concepts
ChemistryPhotocatalysisSurface modificationCombinatorial chemistryFormal synthesisFunctional groupCatalysisReaction conditionsPhotoredox catalysisOrganic chemistryHydrogen atomKetoneReductive eliminationHydrogenMoleculeReaction mechanismAtom economyTransfer hydrogenationSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsRadical Photochemical Reactions