Exploring synthetic and therapeutic prospects of new thiazoline derivatives as aldose reductase (ALR2) inhibitors
Muhammad Tariq Shehzad, Aqeel Imran, Abdul Hameed, Mariya al‐Rashida, Marium Bibi, Maliha Uroos, Asnuzilawati Asari, Shafia Iftikhar, Habsah Mohamad, Muhammad Nawaz Tahir, Zahid Shafiq, Jamshed Iqbal
Abstract
value of 3.14 ± 0.02 μM. Compound 7b with only 23.4% inhibition for ALR1 showed excellent selectivity for the targeted ALR2 to act as a potential lead for the development of new therapeutic agents for diabetic complications.
Topics & Concepts
Aldose reductaseSorbinilSubstituentChemistryAldose reductase inhibitorThiazolineAldehyde ReductaseIC50StereochemistrySelectivityEnzymePharmacologyCombinatorial chemistryBiochemistryIn vitroMedicineCatalysisAldose Reductase and TaurineEicosanoids and Hypertension PharmacologyMacrophage Migration Inhibitory Factor