The highly expressed GOLPH3 in colorectal cancer cells activates smoothened to drive glycolysis and promote cancer cell growth and radiotherapy resistance
Kunli Zhu, Jing Fan, Hongchao Cai, Changchun Zhou, Zhe Gong, Zhenxiang Li, Jinming Yu
Abstract
Background: ) in CRC. Methods: were predicted via Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. Results: . Conclusions: promoted CRC progression and enhanced radiotherapy resistance via glycolysis mediated by the SMO-AMPK axis.
Topics & Concepts
MedicineSmoothenedColorectal cancerCancer researchCancerRadiation therapyGlycolysisCell growthOncologyInternal medicineCell biologyMetabolismBiochemistryHedgehog signaling pathwaySignal transductionBiologyCancer, Hypoxia, and MetabolismDrug Transport and Resistance MechanismsLiver Disease Diagnosis and Treatment