Respiratory Vaccination with Hemagglutinin Nanoliposomes Protects Mice from Homologous and Heterologous Strains of Influenza Virus
Zachary R. Sia, Kevin Chiem, Wei‐Chiao Huang, Amal Seffouh, Amir Teimouri Dereshgi, Tara Hogan, Joaquı́n Ortega, Bruce A. Davidson, Luis Martínez‐Sobrido, Jonathan F. Lovell
Abstract
A self-assembling influenza virus vaccine platform that seamlessly converts soluble antigens into nanoparticles is demonstrated with various H1N1 and H3N2 influenza antigens to protect mice against influenza virus challenge following intranasal vaccination. Mucosal immune responses following liposome delivery to lung antigen-presenting cells are demonstrated.
Topics & Concepts
Hemagglutinin (influenza)VaccinationVirologyNasal administrationAntigenBiologyVirusImmune systemAdjuvantHeterologousImmunizationImmunologyInfluenza vaccineInfluenza A virusMicrobiologyBiochemistryGeneInfluenza Virus Research StudiesImmunotherapy and Immune ResponsesImmune Response and Inflammation