The MttB superfamily member MtyB from the human gut symbiont Eubacterium limosum is a cobalamin-dependent γ-butyrobetaine methyltransferase
Jared Ellenbogen, Ruisheng Jiang, Duncan J. Kountz, Liwen Zhang, Joseph A. Krzycki
Abstract
, providing a rationale for MtyB abundance in γ-butyrobetaine-grown cells. As TMA is readily produced from γ-butyrobetaine, organisms with MtyB-like proteins may provide a means to lower levels of TMA and proatherogenic TMA-N-oxide via precursor competition.
Topics & Concepts
EubacteriumCorrinoidBiochemistryBiologyMethyltransferaseBetaineCobalaminPeptostreptococcusMethylationChemistryAnaerobic bacteriaBacteriaVitamin B12GeneGeneticsFolate and B Vitamins ResearchMetabolism and Genetic DisordersPorphyrin Metabolism and Disorders