Development of Fluoroquinolone Resistance through Antibiotic Tolerance in Campylobacter jejuni
Myungseo Park, Jinshil Kim, Jill Feinstein, Kevin S. Lang, Sangryeol Ryu, Byeonghwa Jeon
Abstract
C. jejuni. Importantly, these antibiotics are commonly used in animal agriculture. Moreover, our study suggests that the use of non-FQ drugs in animal agriculture promotes FQ resistance development, which is crucial because antibiotic-resistant C. jejuni is primarily transmitted from animals to humans. Overall, these findings increase our understanding of the mechanisms of resistance development through the induction of antibiotic tolerance.
Topics & Concepts
Campylobacter jejuniMultidrug toleranceCiprofloxacinAntibioticsAntibiotic resistanceTetracyclineMicrobiologyBiologyErythromycinBacteriaGeneticsBiofilmSalmonella and Campylobacter epidemiologyAntibiotic Resistance in BacteriaVibrio bacteria research studies