The RNA helicase DHX36–G4R1 modulates C9orf72 GGGGCC hexanucleotide repeat–associated translation
Yi‐Ju Tseng, Siara N. Sandwith, Katelyn M. Green, Antonio E. Chambers, Amy Krans, Heather M. Raimer, Meredith E. Sharlow, Michael Reisinger, Adam E. Richardson, Eric D. Routh, Melissa A. Smaldino, Yuh‐Hwa Wang, James P. Vaughn, Peter K. Todd, Philip J. Smaldino
Abstract
repeat translation, providing potential implications for therapeutic development in nucleotide repeat expansion disorders.
Topics & Concepts
Trinucleotide repeat expansionHelicaseRNA Helicase ATranslation (biology)BiologyC9orf72GeneticsRanRNACell biologyMolecular biologyMessenger RNAGeneAlleleRNA Research and SplicingNeurogenetic and Muscular Disorders ResearchRNA and protein synthesis mechanisms