Tuning the immune system by nanoparticle–biomolecular corona
Valentina Palmieri, Giulio Caracciolo
Abstract
as it can activate the immune system triggering inflammatory responses, clearance from the body, and cellular toxicity. In this review, we summarize and critically analyze progress in understanding the relationship between the biological identity of nanoparticles and immune system activation. Accordingly, we discuss the implications of biomolecular corona on nanotoxicity, immune safety, and biocompatibility. We also highlight a perspective on engineering the biological identity of nanoparticles for modulating immunological responses.
Topics & Concepts
NanotechnologyNanomaterialsImmune systemCorona (planetary geology)NanoparticleMaterials scienceAstrobiologyMedicineBiologyImmunologyVenusNanoparticle-Based Drug DeliveryAdvanced biosensing and bioanalysis techniquesBiosensors and Analytical Detection