Sensitive hydrazine detection and quantification with a fluorescent benzothiadiazole sensor: selective lipid droplets and<i>in vivo</i>imaging
Camila O. dos Santos, Saulo T. A. Passos, Jenny E. P. Sorto, Daniel F. S. Machado, José R. Corrêa, Eufrânio N. da Silva Júnior, Marcelo O. Rodrigues, Brenno A. D. Neto
Abstract
A selective hydrazine sensor in solution based on the 2,1,3-benzothiadiazole heterocycle is efficient for in vitro and in vivo analyses. This sensor generates water as the only byproduct, avoiding generation of toxic compounds and interference during in vivo applications.
Topics & Concepts
In vivoChemistryHydrazine (antidepressant)FluorescenceCombinatorial chemistryIn vitroNanotechnologyBiophysicsChromatographyBiochemistryMaterials scienceBiotechnologyQuantum mechanicsPhysicsBiologyElectrochemical sensors and biosensorsMetabolomics and Mass Spectrometry StudiesLipid metabolism and biosynthesis