Harnessing the chemokine system to home CAR-T cells into solid tumors
Jade Foeng, Iain Comerford, Shaun R. McColl
Abstract
CAR-T cell therapy has been heralded as a breakthrough in the field of immunotherapy, but to date, this success has been limited to hematological malignancies. By harnessing the chemokine system and taking into consideration the chemokine expression profile in the tumor microenvironment, CAR-T cells may be homed into tumors to facilitate direct tumor cell cytolysis and overcome a major hurdle in generating effective CAR-T cell responses to solid cancers.
Topics & Concepts
ChemokineImmunotherapyCancer researchTumor microenvironmentCytolysisChemokine receptorMedicineTumor cellsImmunologyBiologyImmune systemCytotoxic T cellIn vitroBiochemistryCAR-T cell therapy researchImmunotherapy and Immune ResponsesVirus-based gene therapy research