Degradable polyprodrugs: design and therapeutic efficiency
Farzad Seidi, Yajie Zhong, Huining Xiao, Yongcan Jin, Daniel Crespy
Abstract
-nitrophenyl groups) and enzyme-responsive linkages (ester, peptides) allow for a selective degradation of the polymer backbone in targeted tumors. We envision that new strategies providing a more efficient synergistic therapy will be developed by combining polyprodrugs with gene delivery segments and targeting moieties.
Topics & Concepts
Therapeutic effectChemistryBiochemical engineeringPharmacologyMedicineEngineeringNanoparticle-Based Drug DeliveryAdvanced Polymer Synthesis and CharacterizationGraphene and Nanomaterials Applications