Brain injury after cardiac arrest: pathophysiology, treatment, and prognosis
Claudio Sandroni, Tobias Cronberg, Mypinder S. Sekhon
Abstract
Post-cardiac arrest brain injury (PCABI) is caused by initial ischaemia and subsequent reperfusion of the brain following resuscitation. In those who are admitted to intensive care unit after cardiac arrest, PCABI manifests as coma, and is the main cause of mortality and long-term disability. This review describes the mechanisms of PCABI, its treatment options, its outcomes, and the suggested strategies for outcome prediction.
Topics & Concepts
MedicineComa (optics)ResuscitationAnesthesiologyIntensive care unitPathophysiologyIntensive care medicineClinical deathIntensive careIschemiaCardiopulmonary resuscitationAnesthesiaCardiologyInternal medicinePhysicsOpticsCardiac Arrest and ResuscitationTraumatic Brain Injury and Neurovascular DisturbancesTraumatic Brain Injury Research