Molecular determinants of pro-arrhythmia proclivity of d- and l-sotalol via a multi-scale modeling pipeline
Kevin R. DeMarco, Pei‐Chi Yang, Vikrant Singh, Kazuharu Furutani, John R.D. Dawson, Mao-Tsuen Jeng, James C. Fettinger, Slava Bekker, Van A. Ngo, Sergei Y. Noskov, Vladimir Yarov‐Yarovoy, Jon T. Sack, Heike Wulff, Colleen E. Clancy, Igor Vorobyov
Topics & Concepts
SotalolhERGProarrhythmiaQT intervalLong QT syndromeTorsades de pointesCardiac electrophysiologyChemistryPharmacologyPotassium channelCardiologyInternal medicineMedicineElectrophysiologyAtrial fibrillationCardiac electrophysiology and arrhythmiasIon channel regulation and functionElectrochemical Analysis and Applications