Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage
Qiang Luo, Panpan Xian, Tian Wang, Shengxi Wu, Tangna Sun, Wenting Wang, Bo Wang, Hao Yang, Yanping Yang, Han Wang, Weiping Liu, Qianfa Long
Abstract
We have shown that MSC-EVs facilitate the reconstruction of hippocampal neurons associated with the Nrf2 defense system in response to oxidative insults. Our study highlights the clinical value of EV-therapy in neurological disorders such as seizures.
Topics & Concepts
Oxidative stressCell biologySuperoxide dismutaseMesenchymal stem cellChemistryNeuroprotectionAntioxidantHippocampal formationPharmacologyReactive oxygen speciesBiologyNeuroscienceBiochemistryExtracellular vesicles in diseaseNeuroinflammation and Neurodegeneration MechanismsMicroRNA in disease regulation