Enantioselective α‐Carbonylative Arylation for Facile Construction of Chiral Spirocyclic β,β′‐Diketones
Ting Wu, Qinghai Zhou, Wenjun Tang
Abstract
We herein describe the first enantioselective α-carbonylative arylation, providing a diverse set of chiral spiro β,β'-diketones bearing various ring sizes and functionalities in high yields and good to excellent enantioselectivities. Calculations suggest the transformation proceeds through reductive elimination instead of nucleophilic addition pathway.
Topics & Concepts
Enantioselective synthesisNucleophileCombinatorial chemistryChemistryRing (chemistry)CatalysisTransformation (genetics)StereochemistryOrganic chemistryBiochemistryGeneAsymmetric Synthesis and CatalysisCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and Catalysis