Palladium-Catalyzed Direct Arylation of 2-Pyridylmethyl Silanes with Aryl Bromides
Tingzhi Lin, Peng‐Cheng Qian, Yan‐En Wang, Mingjie Ou, Long Jiang, Chen Zhu, Yuchuan Xu, Dan Xiong, Jianyou Mao
Abstract
The first palladium-catalyzed direct arylation of 2-pyridylmethyl silanes with aryl bromides to generate a diverse array of aryl(2-pyridyl)-methyl silane derivatives has been developed. This protocol facilitates access to various kinds of heterocycle-containing silanes in good to excellent yields (40 examples, 66-97% yield) with good functional group tolerance. The scalability of this transformation is demonstrated.
Topics & Concepts
SilanesArylChemistrySilaneCatalysisPalladiumFunctional groupYield (engineering)Combinatorial chemistryOrganic chemistryAlkylMaterials sciencePolymerMetallurgyCatalytic Cross-Coupling ReactionsOrganoboron and organosilicon chemistryCatalytic C–H Functionalization Methods