E proteins orchestrate dynamic transcriptional cascades implicated in the suppression of the differentiation of group 2 innate lymphoid cells
Vincent Peng, Constantin Georgescu, Anna Bakowska, Aneta Pankow, Liangyue Qian, Jonathan D. Wren, Xiao-Hong Sun
Abstract
The large number of genes repressed by gain of E protein function leads to the down-regulation of a transcriptional network important for ILC2 differentiation.
Topics & Concepts
Innate lymphoid cellBiologyChromatinRepressorTranscription factorPolycomb-group proteinsInnate immune systemImmune systemCell biologyGeneFunction (biology)Transcriptional regulationLymphopoiesisRegulation of gene expressionHaematopoiesisGeneticsStem cellIL-33, ST2, and ILC PathwaysImmune Cell Function and InteractionEosinophilic Esophagitis