Lower Risk of Multisystem Inflammatory Syndrome in Children With the Delta and Omicron Variants of Severe Acute Respiratory Syndrome Coronavirus 2
Jonathan Cohen, Michael J. Carter, Ronny Cheung, Shamez Ladhani, for the Evelina Paediatric Inflammatory Multisystem Syndrome Temporally related to SARS-CoV-2 (PIMS-TS) Study Group
Abstract
Little is known about the risk of multisystem inflammatory syndrome in children (MIS-C) with different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. In southeast England, MIS-C rates per confirmed SARS-CoV-2 infections in children aged 0-16 years were 56% lower (rate ratio [RR], 0.34 [95% confidence interval {CI}, .23-.50]) during prevaccine Delta, 66% lower (RR, 0.44 [95% CI, .28-.69]) during postvaccine Delta, and 95% lower (RR, 0.05 [95% CI, .02-.10]) during the Omicron period.
Topics & Concepts
MedicineConfidence intervalRelative riskSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Respiratory systemCoronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakInternal medicinePediatricsGastroenterologyVirologyDiseaseOutbreakInfectious disease (medical specialty)Kawasaki Disease and Coronary ComplicationsCOVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Research