Identification of a dual acting SARS-CoV-2 proteases inhibitor through in silico design and step-by-step biological characterization
Veronica Di Sarno, Gianluigi Lauro, Simona Musella, Tania Ciaglia, Vincenzo Vestuto, Marina Sala, Maria Carmina Scala, Gerardina Smaldone, Francesca Di Matteo, Sara Novi, Mario Felice Tecce, Ornella Moltedo, Giuseppe Bifulco, Pietro Campiglia, Isabel Gómez‐Monterrey, Robert Snoeck, Graciela Andreï, Carmine Ostacolo, Alessia Bertamino
Topics & Concepts
ProteasesIn silicoChemistryProteaseDrug discoveryVero cellProtease inhibitor (pharmacology)IC50PotencyDrug repositioningIn vitroPharmacologyDrugComputational biologyEnzymeBiochemistryVirologyBiologyVirusViral loadAntiretroviral therapyGeneSARS-CoV-2 and COVID-19 ResearchViral Infections and Outbreaks ResearchMosquito-borne diseases and control