Is Protein BLAST a thing of the past?
Ali Al-Fatlawi, Martin Menzel, Michael Schroeder
Abstract
Will protein structure search tools like AlphaFold replace protein sequence search with BLAST? We discuss the promises, using structure search for remote homology detection, and why protein BLAST, as the leading sequence search tool, should strive to incorporate structural information
Topics & Concepts
Sequence homologyComputer scienceProtein sequencingSequence (biology)Computational biologyProtein structureHomology (biology)BioinformaticsPeptide sequenceBiologyGeneticsGeneBiochemistryProtein Structure and DynamicsGenomics and Phylogenetic StudiesMachine Learning in Bioinformatics