Cas9-induced targeted integration of large DNA payloads in primary human T cells via homology-mediated end-joining DNA repair
Beau R. Webber, Matthew J. Johnson, Joseph G. Skeate, Nicholas J. Slipek, Walker S. Lahr, Anthony P. DeFeo, Lauren J. Mills, Xiaohong Qiu, Blaine Rathmann, Miechaleen D. Diers, Bryce Wick, Tom Henley, Modassir Choudhry, Timothy K. Starr, R. Scott McIvor, Branden S. Moriarity
Topics & Concepts
Chimeric antigen receptorBiologyCRISPRViral vectorDNAGenetically modified organismCell biologyMolecular biologyImmune systemComputational biologyT cellGeneticsRecombinant DNAGeneVirus-based gene therapy researchCAR-T cell therapy researchCRISPR and Genetic Engineering