Visible-light-induced selective alkylsulfonylation of unactivated alkenes via remote heteroaryl migrations
Xin Yuan, Jie Liu, Hao Lv, Long‐Zhou Qin, Xiu Duan, Jian Wang, Meng‐Yu Wu, Beining Chen, Jiang‐Kai Qiu, Kai Guo
Abstract
Photocatalyzed alkylsulfonylation of unactivated alkenes using DABCO. (SO2)2 and thianthrenium salts via a distal heteroaryl migration process has been developed, which provides a new means of synthesizing a variety of valuable alkylsulfonyl-substituted compounds. These alkylsulfonyl radicals couple with unactivated alkenes to undergo efficient intermolecular reactions, followed by distal heteroaryl migration. This mild catalytic method is tolerant of functional groups and affords medicinally relevant alkylsulfonylated heterocycles.
Topics & Concepts
DABCORadicalChemistryCatalysisIntermolecular forceCombinatorial chemistryOrganic chemistryMoleculeSulfur-Based Synthesis TechniquesRadical Photochemical ReactionsChemical Synthesis and Reactions