Design, synthesis and biological evaluations of a long-acting, hypoxia-activated prodrug of fasudil, a ROCK inhibitor, to reduce its systemic side-effects
Taslim A. Al‐Hilal, Mohammad Anwar Hossain, Ahmed Alobaida, Farzana Alam, Ali Keshavarz, Eva Nozik‐Grayck, Kurt R. Stenmark, Nadezhda German, Fakhrul Ahsan
Topics & Concepts
FasudilProdrugHypoxia (environmental)PharmacologyRho kinase inhibitorChemistryRho-associated protein kinaseMedicineBiochemistryKinaseOxygenOrganic chemistryCancer, Hypoxia, and MetabolismProtein Kinase Regulation and GTPase SignalingNitric Oxide and Endothelin Effects