Testing Implications of the Omnigenic Model for the Genetic Analysis of Loci Identified through Genome-wide Association
Wenyu Zhang, R. G. Reeves, Diethard Tautz
Abstract
and showed that most of these candidate genes are indeed involved in the phenotype. We then randomly chose genes below a GWA significance threshold and found that three-quarters of them had also an effect on the trait with comparable effect sizes as the GWA candidate genes. We further tested the effects of these knockout lines on an independent behavioral pupal trait (pupation site choice) and found that a similar fraction had a significant effect as well. Our data thus confirm the implication that a large number of genes can influence independent quantitative traits.
Topics & Concepts
BiologyGenome-wide association studyGeneticsEvolutionary biologyAssociation (psychology)Genetic associationGenomeComputational biologyGeneSingle-nucleotide polymorphismGenotypePhilosophyEpistemologyGenetic Mapping and Diversity in Plants and AnimalsGenetic Associations and EpidemiologyEvolution and Genetic Dynamics