Tofacitinib citrate-based liposomes for effective treatment of rheumatoid arthritis.
Qiying Shen, Huan Shu, Xiaoling Xu, Gaofeng Shu, Yongzhong Du, Xiaoying Ying
Abstract
studies showed that TOF loaded liposomes (TOFL) could be selectively taken up by inflamed cells and showed improved accumulation in arthritic paws, demonstrating the superior target ability to RA tissues. Moreover, compared to free TOF, TOFL significantly improved the therapeutic efficacy, reduced the inflammatory cytokine expression and lipid peroxidation in synovial cells in the joint tissue of RA rats. Overall, these results indicate that TOFL served as the useful nanocarriers for RA-targeted therapy.
Topics & Concepts
TofacitinibRheumatoid arthritisLiposomeMedicinePharmacologyInternal medicineChemistryBiochemistryMonoclonal and Polyclonal Antibodies ResearchRheumatoid Arthritis Research and TherapiesSystemic Lupus Erythematosus Research