Smartphone clip-on instrument and microfluidic processor for rapid sample-to-answer detection of Zika virus in whole blood using spatial RT-LAMP
Aaron Jankelow, Hankeun Lee, Weijing Wang, Trung-Hieu Hoang, Amanda Bacon, Fu Sun, Seol Chae, Victoria Kindratenko, Katherine Koprowski, Robert A. Stavins, Dylann D. Ceriani, Zachary W. Engelder, William P. King, N. Minh, Rashid Bashir, Enrique Valera, Brian T. Cunningham
Abstract
Rapid, simple, inexpensive, accurate and sensitive point-of-care (POC) detection of viral pathogens in bodily fluids is a vital component of controlling the spread of infectious diseases.
Topics & Concepts
Loop-mediated isothermal amplificationMicrofluidicsZika virusCartridgeNucleic acidDetection limitLab-on-a-chipComputer hardwareComputer scienceVirologyNanotechnologyChromatographyBiologyVirusMaterials scienceChemistryDNAMetallurgyBiochemistryGeneticsMosquito-borne diseases and controlBiosensors and Analytical Detection