<i>Dlt</i> Operon Regulates Physiological Function and Cariogenic Virulence in <i>Streptococcus Mutans</i>
Jingyun Du, Shan Huang, Minjing Wu, Shuai Chen, Wen Zhou, Ling Zhan, Xiaojing Huang
Abstract
Streptococcus mutans is one of the major cariogenic pathogens in the oral cavity. The dlt operon is responsible for the process of D-alanylation of lipoteichoic acid and is related to the virulence of S. mutans. The dlt operon contributes to the adhesion, biofilm formation, stress response, interspecies competitiveness and autolysis of S. mutans. In addition, we have summarized the possible regulatory networks of the dlt operon. This review highlights the significant role of the dlt operon in S. mutans and provides new ideas for ecological caries prevention.
Topics & Concepts
Streptococcus mutansOperonBiofilmMicrobiologyLipoteichoic acidVirulenceAutolysis (biology)BiologyGlucosyltransferasesBacteriaGeneticsGeneMutantBiochemistryStaphylococcus aureusEnzymeOral microbiology and periodontitis researchCancer Research and TreatmentsSalivary Gland Disorders and Functions