GLP‐1 and Dual GLP‐1/GIP Receptor Agonists in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Systematic Review and Meta‐Analysis
Mushood Ahmed, Muhammad Burhan, Aimen Shafiq, Tallal Mushtaq Hashmi, Raheel Ahmed, Marat Fudim, Robert J. Mentz, Gregg C. Fonarow
Abstract
This comprehensive meta-analysis reveals that GLP-1 and dual GLP-1/GIP receptor agonists are associated with reduced risk of composite cardiovascular endpoints and worsening heart failure events. However, no statistically significant differences were observed regarding all-cause or cardiovascular mortality.
Topics & Concepts
MedicineHeart failureInternal medicineCardiologyAgonistHeart failure with preserved ejection fractionReceptorDual (grammatical number)B2 receptorEndocrinologyHeart diseaseEjection fractionBlockadeDiabetes Treatment and ManagementHyperglycemia and glycemic control in critically ill and hospitalized patientsHeart Failure Treatment and Management