Targeting Cancer Stem Cells by Genetically Engineered Chimeric Antigen Receptor T Cells
Rowa Y. Alhabbab
Abstract
, the interaction between CSCs and the immune system, CAR T cell genetic engineering and signaling, CAR T cells in targeting CSCs, and the barriers in using CAR T cells as immunotherapy to treat solid cancers.
Topics & Concepts
Chimeric antigen receptorCancer stem cellCD44Cancer researchStem cellCancerCD90AntigenCancer cellCancer immunotherapyImmunotherapyBiologyImmunologyImmune systemCellCell biologyGeneticsCAR-T cell therapy researchImmunotherapy and Immune ResponsesCancer Cells and Metastasis