Design, synthesis and evaluation of novel bis-substituted aromatic amide dithiocarbamate derivatives as colchicine site tubulin polymerization inhibitors with potent anticancer activities
Yaxin Sun, Jian Song, Lijun Kong, Beibei Sha, Xin-Yi Tian, Xiujuan Liu, Tao Hu, Ping Chen, Sai‐Yang Zhang
Topics & Concepts
ChemistryTubulinColchicineMicrotubule polymerizationMicrotubuleLinkerApoptosisLead compoundStereochemistryDocking (animal)BiochemistryIn vitroCell biologyBiologyGeneticsComputer scienceMedicineNursingOperating systemSynthesis and biological activitySynthesis of heterocyclic compoundsSynthesis and Characterization of Heterocyclic Compounds