Litcius/Paper detail

Design, synthesis and evaluation of novel bis-substituted aromatic amide dithiocarbamate derivatives as colchicine site tubulin polymerization inhibitors with potent anticancer activities

Yaxin Sun, Jian Song, Lijun Kong, Beibei Sha, Xin-Yi Tian, Xiujuan Liu, Tao Hu, Ping Chen, Sai‐Yang Zhang

2021European Journal of Medicinal Chemistry42 citationsDOI

Topics & Concepts

ChemistryTubulinColchicineMicrotubule polymerizationMicrotubuleLinkerApoptosisLead compoundStereochemistryDocking (animal)BiochemistryIn vitroCell biologyBiologyGeneticsComputer scienceMedicineNursingOperating systemSynthesis and biological activitySynthesis of heterocyclic compoundsSynthesis and Characterization of Heterocyclic Compounds