Metal-free synthesis of functionalized tacrine derivatives and their evaluation for acetyl/butyrylcholinesterase and α-glucosidase inhibition
Thangellapally Shirisha, Subir Majhi, K. Divakar, Dhurke Kashinath
Abstract
The synthesis, in vitro activity, docking and molecular dynamics of tacrine derivatives were studied for AChE, BChE and α-glucosidase inhibition. It was found that many of the reported compounds here showed better activity than standard drugs.
Topics & Concepts
ChemistryTacrineButyrylcholinesteraseIC50StereochemistryOrganic chemistryCombinatorial chemistryMedicinal chemistryAchéEnzymeAcetylcholinesteraseIn vitroBiochemistryCholinesterase and Neurodegenerative DiseasesEnzyme function and inhibitionSynthesis and biological activity