Natural flavonoid hesperetin blocks amyloid β-protein fibrillogenesis, depolymerizes preformed fibrils and alleviates cytotoxicity caused by amyloids
Qinchen Dong, Zhan Cui, Xinming Wu, Li Li, Fuping Lu, Fufeng Liu
Abstract
, including the inhibition of the formation and deposition of Aβ aggregates and extension of their lifespan. Finally, the results of molecular dynamics simulations showed that hesperetin directly interacted with an Aβ42 pentamer mainly through strong non-polar and electrostatic interactions, which destroyed the structural stability of the preformed pentamer. To summarize, hesperetin exhibits great potential as a prospective dietary supplement for preventing and improving AD.
Topics & Concepts
HesperetinPentamerChemistryCytotoxicityFibrilFlavonoidBiophysicsHesperidinProtein aggregationAmyloid (mycology)BiochemistryAntioxidantIn vitroBiologyMedicinePathologyInorganic chemistryAlternative medicineAlzheimer's disease research and treatmentsCholinesterase and Neurodegenerative DiseasesGraph theory and applications