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Human PLD structures enable drug design and characterization of isoenzyme selectivity

Claire M. Metrick, Emily A. Peterson, Joseph C. Santoro, Istvan Enyedy, Paramasivam Murugan, TeYu Chen, Klaus Michelsen, Michael L. Cullivan, Kerri Spilker, P. Rajesh Kumar, Tricia L. May‐Dracka, Jayanth V. Chodaparambil

2020Nature Chemical Biology38 citationsDOI

Topics & Concepts

IsozymeEnzymePhosphatidic acidPhospholipase DBiochemistryGene isoformBiologyDrug discoveryHomology modelingChemistryComputational biologyGeneMembranePhospholipidCholinesterase and Neurodegenerative DiseasesPhosphodiesterase function and regulationEnzyme function and inhibition
Human PLD structures enable drug design and characterization of isoenzyme selectivity | Litcius