High-efficiency brain-targeted intranasal delivery of BDNF mediated by engineered exosomes to promote remyelination
Yuanxin Zhai, Quanwei Wang, Zhanchi Zhu, Ying Hao, Fang Han, Jing Hong, Wenlong Zheng, Sancheng Ma, Lingyan Yang, Guosheng Cheng
Abstract
. The intranasal administration of the brain-targeted engineered exosome-mediated BDNF was a highly effective delivery route to the brain and had a significant therapeutic effect on remyelination and motor coordination ability improvement in demyelination model mice. The combination of intranasal administration with brain-targeted and BDNF-loaded designed exosomes provides a strategy for efficient drug delivery and treatment of central nervous system diseases.
Topics & Concepts
RemyelinationNasal administrationMicrovesiclesNeuroscienceChemistryExosomeMedicineBiologyCentral nervous systemPharmacologymicroRNABiochemistryMyelinGeneRNA Interference and Gene DeliveryExtracellular vesicles in diseaseMicroRNA in disease regulation