New trinuclear nickel(II) complexes as potential topoisomerase I/IIα inhibitors: in vitro DNA binding, cleavage and cytotoxicity against human cancer cell lines
Tolga Göktürk, Cansu Topkaya, Esin Sakallı Çetin, Ramazan Güp
Topics & Concepts
ChemistryTopoisomeraseCytotoxicityCell cultureMolecular biologyAgarose gel electrophoresisMTT assayDNAApoptosisBiochemistryIn vitroBiologyGeneticsMetal complexes synthesis and propertiesCancer therapeutics and mechanismsSynthesis and Biological Evaluation