GenX analogs exposure induced greater hepatotoxicity than GenX mainly via activation of PPARα pathway while caused hepatomegaly in the absence of PPARα in female mice
Wanlan Ren, Zhiru Wang, Hua Guo, Yong Gou, Jiayin Dai, Xuming Zhou, Nan Sheng
Topics & Concepts
Peroxisome proliferator-activated receptorReceptorChemistryNuclear receptorPeroxisomeEndocrinologyInternal medicinePharmacologyBiologyBiochemistryMedicineTranscription factorGenePer- and polyfluoroalkyl substances researchPeroxisome Proliferator-Activated ReceptorsRetinoids in leukemia and cellular processes