Copper(II) Trimethylacetate Complex with Caffeine: Synthesis, Structure, and Biological Activity
Dmitriy S. Yambulatov, Stanislav A. Nikolaevskii, Irina А. Lutsenko, Mikhail A. Kiskin, Maxim A. Shmelev, Olga B. Bekker, Nikolay N. Efimov, Elena A. Ugolkova, Vadim V. Minin, А.А. Sidorov, И.Л. Еременко
Abstract
The reaction of copper(II) trimethylacetate, [Cu(Piv)2]n (Piv = C(Me)3COO–), with caffeine (L) (Cu : L = 1 : 1) in anhydrous acetonitrile yielded the binuclear complex [Cu2(Piv)4(L)2] ⋅ 2CH3CN (I). The structure of the complex in the crystal was established by X-ray diffraction (CIF file CCDC no. 2 006 753), and the electronic structure was studied by ESR. The effect of caffeine coordination to the biogenic complexing agent was established: the in vitro biological activity of the obtained complex towards the non-pathogenic strain Mycolicibacterium smegmatis was eight times higher than that of free caffeine.